Understanding the role of zinc and zinc transporters in Autism
TitleUnderstanding the role of zinc and zinc transporters in Autism
NameDe Benedectis and Grabrucker
The purpose of this study is to investigate the expression and the localisation of zinc transporters in neural tissue (neurons and glial cells) with a particular focus on zinc transporter 5 (ZnT5). A mutation in the zinc transporter ZnT5 (missense mutation p.S561R) was linked to autism in human patients.
The hypothesis in this study is that a loss of function in the transporter ZnT5 in the offspring, despite normal zinc status of the mother, may lead to insufficient zinc supply during a critical time window in brain development, which may be linked to the development of autism.